--- title: Anxiety, Stress and Resilience in the Brain description: The ventral medial prefrontal cortex part of the brain shows greater flexibility in people who cope better with stress, finds a new study canonical: https://time.com/4411308/stress-resilience-brain-anxiety/ author: Mandy Oaklander article:opinion: false article:content_tier: free article:published_time: 2016-07-20T13:44:06.000Z article:modified_time: 2026-02-22T23:20:11.552Z article:section: Health og:title: Here's Why Some People Handle Stress Better Than Others og:description: The ventral medial prefrontal cortex part of the brain shows greater flexibility in people who cope better with stress, finds a new study og:url: https://time.com/4411308/stress-resilience-brain-anxiety/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt15a91bceeb2d66f6/69889c63524fc0ce8fdf8c41/anxiety-hands.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 3888 og:image:height: 2187 og:image:alt: anxiety hands og:type: article twitter:card: summary_large_image twitter:title: Here's Why Some People Handle Stress Better Than Others twitter:description: The ventral medial prefrontal cortex part of the brain shows greater flexibility in people who cope better with stress, finds a new study twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt15a91bceeb2d66f6/69889c63524fc0ce8fdf8c41/anxiety-hands.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Why Some People Handle Stress Better Than Others > Sponsored content. 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Brief (Washington politics, three times a week), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement.  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Jul 20, 2016 1:44 PM UTC  Getty Images  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Jul 20, 2016 1:44 PM UTC A quick scan of any recent headline would reveal that humans live in a highly stressed world, full of violence, terror and hate. Sometimes, it’s a wonder we can go on with our lives at all. (If that feels like you, see this recent piece about [How to Cope When the World Feels Like Total Chaos](http://time.com/4411183/how-to-cope-when-the-world-feels-like-total-chaos/).) “There is a drive to cope and to survive,” says Rajita Sinha, director of the Yale Stress Center and lead author of a new [study](http://www.pnas.org/content/early/2016/07/13/1600965113) published in the journal _Proceedings of the National Academy of Sciences_. Yet we all respond to stress differently, and [some of us are more resilient than others](http://time.com/3892044/the-science-of-bouncing-back/?iid=sr-link3). But why? Sinha and her colleagues wanted to look inside people’s brains during a stressful situation to see if anything special was happening to help people cope better with stress. They recruited 30 healthy people and put them in an fMRI scan session for six long minutes, during which they were shown either stressful or neutral images. “When you get stressed, it’s not brief—it goes on for a little bit,” Sinha says. “And that’s the state in which the brain has to figure out what to do.” The stressed group was shown 60 scary, violent images, like people being shot, maimed, stabbed and chased. The control group saw neutral images like tables, chairs and lamps. The researchers later asked people about some of the ways they cope with stress, including alcohol intake, eating behaviors, and how often they get into arguments. During stress, the researchers saw something interesting happening in one particular area of the brain: the ventral medial prefrontal cortex, a region involved in emotional regulation and detecting one’s own internal state, like hunger, craving and wanting. People who had more neuroflexibility and neuroplasticity in this region were also less likely to be binge drinkers and emotional eaters, and they were less likely to respond to stress in an emotionally destructive way, Sinha says. “The greater the magnitude of the change in the neural signal, the more active copers they were,” she says. The results suggest that this part of the prefrontal cortex is involved in wresting back control during times of stress—a key aspect to resilience. More research is needed to see how to increase flexibility in this region, but Sinha believes theirs is a first step in understanding resilience. “We have a natural circuitry to try to regain control and to be resilient,” Sinha says. “I think it’s tied to the survival processes that are hardwired, and this is what we’re tapping into.” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4411308/stress-resilience-brain-anxiety/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4411308/stress-resilience-brain-anxiety/"},"headline":"Why Some People Handle Stress Better Than Others","datePublished":"2016-07-20T13:44:06.000Z","dateModified":"2026-02-22T23:20:11.552Z","description":"This part of the brain shows greater flexibility in people who cope better with stress","url":"https://time.com/4411308/stress-resilience-brain-anxiety/","keywords":["Research","Depression","Brain","Anxiety","Stress","Terrorism","Terror","resilience"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt15a91bceeb2d66f6/69889c63524fc0ce8fdf8c41/anxiety-hands.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Mandy Oaklander","jobTitle":"Oaklander is a senior editor at TIME.","url":"https://time.com/author/mandy-oaklander/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt15a91bceeb2d66f6/69889c63524fc0ce8fdf8c41/anxiety-hands.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"anxiety hands","caption":"anxiety hands","creditText":"Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/research/","name":"Research"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4411308/stress-resilience-brain-anxiety/","name":"Why Some People Handle Stress Better Than Others"}}]}] ```