January 19, 2004
Health
E L E C T R O N - B E A M C O M P U T E D T O M O G R A P H Y
Much as heart doctors know about the risk factors that contribute
to heart diseasehigh cholesterol, high blood pressure, stress
and lack of physical activitythey still have no reliable way to
predict who will and who won't suffer a heart attack.
Until now. It turns out that excess deposits of calcium in the
lining of the arteries, which can be measured using electron-beam
computed tomography (EBCT), are a good indication that
potentially dangerous fatty plaques exist. The correlation is
strong enough that the American Heart Association is weighing a
recommendation of EBCT screening for healthy adults who have a
greater than average risk of heart disease, including smokers and
those with a strong family history. As an added benefit, patients
can take home their EBCT image, complete with gummed-up arteries,
and use it as a reminder to stick with that exercise program and
low-fat diet.
F
F L U
It was a flu season to remember, but not because it was a
historically bad one. Rather, it was because the annual ordeal
started earlier than usual, took the lives of nearly 100
youngsters and raised concerns that the supply of vaccine
couldn't meet demand and might not be effective against this
year's strain of virus. At the same time, health officials urged
that all healthy babies between the ages of 6 months and 23
months be vaccinated. Thankfully, the worries proved to be
overblown, but as experts at the Centers for Disease Control and
Prevention (CDC) pointed out, when it comes to the flu, it's far
better to be safe than sorry.
G
G R E E N T E A
How healthful is a cup of green tea? Let us count the ways.
Recent studies suggest that chemically active compounds in the
soothing drink may help lower cholesterol, aid the immune system
in fighting off infections, assist in weight loss and protect
against cancers of the lung, colon, breast, liver, prostate,
pancreas, bladder and skin. Tea may also help us prevent diabetes
and bad breath. Keep in mind, though, that the studies are
preliminary and sometimes even contradictory. Enjoy your cup of
tea, but don't expect it to be a cure-all.
H
H R T
Last year put a few more nails in the coffin of long-term
hormone-replacement therapy. Further examination of the data from
the Women's Health Initiative, a study that involved more than
16,000 women, showed that the combination of estrogen and
progestin not only raised a postmenopausal woman's risk of heart
disease and breast cancer but also increased her risk of stroke
and doubled her chances of developing dementia if she was 65 or
older. The grim research results, on top of those released in
2002, have translated into plummeting prescriptions for Wyeth
Pharmaceuticals, manufacturer of Prempro (the company also helped
fund the critical studies): the tally of 2003 sales of the
hormone combo is expected to be down 50% from 2002 sales, which
were down 25% from 2001 sales.
H E A R T
The news reports dubbed it "Drano for the heart," and if the
results are confirmed in larger trials, they may signal an
exciting new approach in fighting cardiovascular disease,
America's leading cause of death. "It" is a genetically rare type
of HDL, or "good" cholesterol, dubbed ApoA-1 Milano. First
identified 30 years ago in a small group of people living in
northern Italy, this super HDL is even more protective against
heart disease than regular HDL. In a study released this past
fall, researchers injected a synthetic version of ApoA-1 Milano
into 47 patients and found that unlike drugs that merely slow the
dangerous buildup of plaque in the arteries, super HDL reduced
the size of the plaquesand did so in the dramatically short
period of five weeks. The experimental drug also stabilized the
plaques that remained and reduced their level of inflammation,
making them less likely to burst. Though the study was too small
to be definitive, it certainly stirred a lot of interest at the
American Heart Association's meeting in November. After years of
being preoccupied with lowering levels of LDL, the "bad"
cholesterol, doctors and patients may soon be focusing on how to
pump up vessel-cleansing HDL.
I
I N S O M N I A
The value of a good night's sleep is hard to overstate. And
researchers are increasingly finding that sleep doesn't just
improve the quality of lifeit actually prolongs life as well.
An analysis of eight sleep studies showed that healthy adults age
60 and older who experienced poor sleepcharacterized by long
stretches of wakefulness during the nighthad double the normal
risk of early death. Other studies link poor sleep to lower
immune-system function as well as an increased risk for certain
types of cancer.
But to what lengths should you go to make sure you get enough
sleep? Today's sleeping pills can help, but are they safe to take
in the long term? The drug company Sepracor has been testing a
new pill, Estorra, that appears to be both safe and effective
when taken for six months. The drug is under review for approval
by the FDA. No doubt competitors will be looking at their own
sleep drugs to see if they can pass the six-month test.
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