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Once an attack starts, over-the-counter analgesics are generally not strong enough to dull the pain.
Triptans are the most popular prescription drugs. These target the brain chemicals that launch the migraine and bring relief within an hour for 3 out of 4 sufferers.
Ergotamine and dihydroergotamine (DHE) are doubly effective. They block the inflammation of nerve cells that activate pain receptors while discouraging nerves from sending pain signals. Other antimigraine medications include corticosteroids, which calm inflamed pain nerves in the brain, and blood-pressure-lowering drugs such as beta-blockers.
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