What Alzheimer's Does to the Brain

TIME Graphic by Lon Tweeten
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The disease is characterized by the gradual spread of sticky plaques and clumps of tangled fibers that disrupt the delicate organization of nerve cells in the brain. As brain cells stop communicating with one another, they atrophy — causing memory and reasoning to fade


1. Tangles and plaques first appear in the entorhinal cortex, an essential memory processing center needed for making new memories and retrieving old ones

2. Over time they move higher, invading the hippocapus, the past of the brain that forms complex memories of events or objects

3. Finally the tangles and plaques reach the top of the brain, or neocortex, the "executive" that sorts through stimuli and orchestrates all behavior

QUOTES OF THE DAY

Open quoteThe oil industry goes up there and industrializes what has been a pristine area... suddenly it becomes the new Houston.Close quote

  • FRANK O'DONNELL,
  • president of the nonprofit group Clean Air Watch, protesting a plan to drill in the Arctic Circle. Experts say the area could fulfill global demand for oil for three years
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