Side Effects of 1918 Flu Seen Decades Later

Runny nose, persistent chill, fever, fatigue — these symptoms are all familiar evidence of influenza. But what about a heart attack, suffered 60 years later?

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Researchers suggest that such distant health problems may be linked to early exposure to the flu — as early as in the womb — according to a new study that analyzed federal survey data collected from 1982 to 1996. Researchers found, for instance, that people who were born in the U.S. just after the 1918 flu pandemic (that is, people who were still in utero when the disease was at its peak) had a higher risk of a heart attack in their adulthood than those born before or long after the pandemic. (See pictures of thermal scanners hunting for swine flu.)

The new findings, published in the Journal of Developmental Origins of Health and Disease, are based largely on survey data available on some 100,000 Americans who were born between 1915 and 1923. Overall, these populations had roughly the same rate of heart attack year to year — about 200 heart attacks per 1,000 people — when they were studied some 60 years later. But among the subset of people born between October 1918 and June 1919, when the flu pandemic was at its worst, the number of heart attacks increased more than 20%.

The study's authors, including Caleb Finch, a professor of gerontology at the University of Southern California, also combed through U.S. Army enlistment data for about 2.7 million men born between 1915 and 1922 and found other trends among flu babies. "Men born in 1919 were shorter by about 0.05 in. relative to surrounding cohorts," says Finch. That's only about a millimeter's difference, or the thickness of a credit card, but he thinks that's significant and somehow related to maternal flu exposure. "I am confident because it's only restricted to that one year," Finch says. (See what you need to know about the H1N1 vaccine.)

In the past decade, there have been several similar studies in the U.S., Britain, Brazil and elsewhere that have come to comparable conclusions. Children born just after flu pandemics have higher rates of physical disability, perform worse in academic tests and have lower income compared with babies born before or after pandemics. "The cohort [born in 1919] has shorter height and lower weight as teenagers, a higher percentage of various health issues," wrote economist Ming-Jen Lin of National Taiwan University in a soon-to-be-published paper looking at the long-term effects of the 1918 flu in Taiwan.

Perhaps the most commonly cited paper is one by researchers at Columbia University, which associated a mother's influenza with her child's risk of mental illness. In that landmark study, researchers collected blood samples from 12,000 pregnant women in Alameda County, California, between 1959 and 1966 and monitored their sons and daughters for more then three decades. Children born to women who had been infected with flu were three to seven times more likely to develop schizophrenia later in life, the study concluded. (See the top 5 swine flu don'ts.)

So what is the link between a mother's influenza and her child's cardiac health, physical stature or risk of mental illness? Well, we don't really know. What we do know is that it's probably not the flu virus itself. There is no known biochemical mechanism that links heart disease or other health outcomes to prenatal exposure to flu. And the flu virus, unlike the pathogens that cause herpes, German measles and syphilis, is not teratogenic — that is, it doesn't cause malformations in the fetus, says Dr. Ellen Harrison, the director of obstetrical medicine at the Montefiore Medical Center in the Bronx, N.Y.

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