The Path To Freedom

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Mark Twain knew how easy it is to give up smoking: he did it a thousand times. An estimated $100 million will be spent this year by British smokers — on medication alone — determined to prove Twain wrong. Only 2% will make it. Here's how to boost the odds.

Physical withdrawal symptoms are best treated with a trip to the pharmacy for nicotine replacement substitutes, in the form of gum, patches, inhalers or lozenges, although scientists reported that nicotine itself may promote cancer.

For many, the best approach may be Zyban (bupropion hydrochloride), a prescription-only antidepressant that counteracts nicotine withdrawal. Introduced in Britain in June 2000, the drug has been used by nearly half a million people, though the Medicines Control Agency reported last year that 57 people had died from suspected adverse reactions to it. Like the nicotine-replacement treatments, Zyban doubles your odds of quitting.

But if you fall back into the habit, take heart. You've still got another 999 chances.