Today neurobiologists no longer argue about whether or not the brain can grow new cells. Instead they're trying to figure out how this cell growth can be harnessed to treat everything from epilepsy to stress to depression. Some have observed that during stress, for example, neurogenesis in the learning center of the brain in several animal species slows considerably-which may help explain depressive episodes that accompany stress.

Gage now believes that changes in behavior like exercising more can affect neurogenesis and alter the brain's wiring. "The idea is that we have control over who we are, even as adults," he says. We're used to thinking that our minds control our bodies. Could it be the other way around? Could what we do change the structure of our brains? It's a radical idea-one that turns on its head accepted ideas of nature vs. nurture. And since Gage has some experience toppling long-standing biological truths, it's probably worth considering.

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Name: Fred Gage
Age: 49
Why critics are taking note: His groundbreaking work in neurogenesis and research with stem cells
Fred Gage

Stem Cells: A Primer

UCSD Neurobiology


THIS MONTH'S INNOVATORS


Will the 21st century produce more important innovations than the last? Who will be the top inventors? Tell us if you agree with TIME's choices.


Which of the following breakthroughs do you think will come first?

The ability to clone humans
A cure for cancer
Extending the average life past 100
Other


Do you know the next Einstein? Is your neighbor working on the next great health breakthrough? If so, e-mail us the name of your nominee, explaining in 50 words or less why we should choose him or her.


Transcript of chat with Sherry Cady, from Sunday, August 6th on CNN.com.

Sherry Cady's on CNN&TIME from her appearance Sunday, August 6th. Learn more about this unique astrobiologist.

Go to the Time 100

About the Series

Rollovers: Adam Arkin by MICHAEL SEXTON/TIME, Sherry Cady by MICHAEL LEWIS/TIME
Fred Gage by DAVID STRICK/TIME, Juan Maldacena by THOMAS MICHAEL ALLEMAN/TIME
Adam Riess by JONATHAN SAUNDERS/TIME, Peter Schultz by MOJGAN AZIMI/TIME
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