Medicine: Fixing a Leaky Valve

The student nurse was still in her teens when rheumatic fever struck. She made an average recovery, but the infection had raged around the aortic valve, through which the heart's blood passes to the great artery for distribution to the rest of the body. As the inflammation died down, the healing valve tissues became scarred and failed to close. Instead of a one-way pulsing flow of blood, there was an unsteady flow with a backwash. For a dozen years the patient got along with rest and digitalis, but six months ago she became much worse. Anginal pain and failing strength forced her to stop working. Her future looked bleak indeed.

Last month, at Georgetown University Medical Center, the young woman (now 30) became the first patient in medical history to be fitted successfully with an artificial aortic valve. (Boston surgeons have slipped a plastic ball into the mitral valve—TIME, March 10). Though she will still have to follow doctor's orders (digitalis, salt rationing and plenty of rest), she is a changed woman—vigorous, gaining strength and hope, and free from the pain of angina.

Dogs First. For Heart Surgeon Charles Hufnagel, 36, the achievement marked the end of more than five years of painstaking work. "In heart ailments," he says, "one of the major problems is leaky valves. There wasn't much that surgery could do about it. So I went back to the beginning, and one of the answers, obviously, was to put in a substitute valve." Dr. Hufnagel soon designed an artificial valve containing a plastic ball float, and began trying it on dogs. It worked.

When several of the dogs had survived for two years or more with plastic valves and no ill effects, Georgetown sponsored Dr. Hufnagel's work and the U.S. Public Health Service helped with funds. The valve, as perfected, is made of Plexiglas and contains a float the size of a mothball which rises and slips into one of three sockets in the side of the valve sleeve on the heart's upbeat, when blood is forced into the aorta. When the heart relaxes between beats, the ball falls into a seat and stops blood from leaking back into the heart.

Dr. Hufnagel and the team of surgeons who joined him in the work performed their first operation on a human patient a year ago. The woman died, but the valve was not the cause of death. Nevertheless, the surgeons spent a long time rechecking both theories and practice (on dogs) before they tried again. The former student nurse was an ideal subject. "She thoroughly understood her case," says Hufnagel. "She read our papers, and she knew exactly what her problem and her chances were."

Though the whole operation (under sodium pentothal and nitrous oxide anesthesia) lasted 2½ hours, most of that time was taken up in getting to the aorta. Then Dr. Hufnagel cut the aorta a few inches from the heart and fitted the loose ends of the aorta to the ends of the plastic valve sleeve. Like a plumber putting an extra valve in a water line, he left the old, defective valve in place. This part of the operation took only five minutes, and the blood flow to the brain was never interrupted.