Smart Genes?

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But a remarkable experiment performed in 1962 by Canadian psychologist Brenda Milner proved that H.M. can form new memories of a very specific sort. For many days running, she asked him to trace a design while looking in a mirror. As far as H.M. knew, the task was a brand-new one each time he confronted it. Yet as the days wore on, his performance improved. Some part of his brain was retaining a memory of an earlier practice session, a so-called implicit--rather than explicit, or consciously remembered--memory. People who suffer from Alzheimer's disease exhibit the same sort of behavior--and it's the medial temporal lobe that is first affected by this devastating disease.

In patients with Huntington's disease, it's the part of the brain called the basal ganglia that's destroyed. While these victims have perfectly intact explicit memory systems, they can't learn new motor skills. An Alzheimer's patient can learn to draw in a mirror but can't remember doing it; a Huntington's patient can't do it but can remember trying to learn. Yet another region of the brain, an almond-size knot of neural tissue known as the amygdala, seems to be crucial in forming and triggering the recall of a special subclass of memories that is tied to strong emotion, especially fear. The hippocampus allows us to remember having been afraid; the amygdala evidently calls up the goosebumps that go along with each such memory.

These are just some of the major divisions. Within the category of implicit (a.k.a. nondeclarative) memory, for example, lie the subcategories of associative memory--the phenomenon that famously led Pavlov's dogs to salivate at the sound of a bell, which they had learned to associate with food--and of habituation, in which we unconsciously file away unchanging features of the environment so we can pay closer attention to what's new and different upon encountering a new experience.

Within explicit, or declarative, memory, on the other hand, there are specific subsystems that handle shapes, textures, sounds, faces, names--even distinct systems to remember nouns vs. verbs. All of these different types of memory are ultimately stored in the brain's cortex, within its deeply furrowed outer layer--a component of the brain dauntingly more complex than comparable parts in lesser species. Experts in brain imaging are only beginning to understand what goes where, and how the parts are reassembled into a coherent whole.

What seems to be a single memory is actually a complex construction. Think of a hammer, and your brain hurriedly retrieves the tool's name, its appearance, its function, its heft and the sound of its clang, each extracted from a different region of the brain. Fail to connect a person's name with his or her face, and you experience the breakdown of that assembly process that many of us begin to experience in our 20s--and that becomes downright worrisome when we reach our 50s.

It was this weakening of memory and the parallel loss of ability to learn new things easily that led Princeton molecular biologist Joe Tsien to the experiments reported last week. "This age-dependent loss of function," he says, "appears in many animals, and it begins with the onset of sexual maturity."