1 TISSUE ENGINEERS With man-made skin already on the market and artificial cartilage not far behind, 25 years from now scientists expect to be pulling a pancreas out of a Petri dish. Or trying, anyway. Researchers have successfully grown new intestines and bladders inside animals' abdominal cavities, and work has begun on building liver, heart and kidney tissue.
2 GENE PROGRAMMERS Digital genome maps will allow lab technicians to create customized prescriptions, altering individual genes by rewriting lines of computer code. After scanning your DNA for defects, doctors will use gene therapy and "smart" molecules to prevent a variety of diseases, including certain cancers.
3 PHARMERS New-age Old MacDonalds will raise crops and livestock that have been genetically engineered to produce therapeutic proteins. Works in progress include a vaccine-carrying tomato and drug-laden milk from cows, sheep and goats.
4 FRANKENFOOD MONITORS Not sure what's for dinner? With a little genetic tinkering, fast-growing fish and freeze-resistant fruits will help feed an overpopulated planet, but such hybrids could unwittingly wipe out the food chain. Eco-scouts will be on the lookout for so-called Trojan gene effects, and bounty hunters will help the USDA eliminate transgenic species that get out of hand.
5 DATA MINERS When Ask Jeeves just won't cut it, research gurus will be on hand to extract useful tidbits from mountains of data, pinpointing behavior patterns for marketers and epidemiologists alike.
6 HOT-LINE HANDYMEN Still daunted by the thought of reprogramming your VCR, let alone your newfangled DVD? Just wait until your 3-D holographic TV won't power up or your talking toaster starts mouthing off. Remote diagnostics will take care of most of your home electronics, but a few repairmen will still make house calls...via video phone.
7 VIRTUAL-REALITY ACTORS Pay-per-view will become pay-per-play, allowing these pros to interact with you in cyberspace dramas. Scriptwriters will also be in high demand, as mouse potatoes clamor for new story lines to escape from their droned-out existence.
8 NARROWCASTERS Today's broadcasting industry will become increasingly personalized, working with advertisers to create content (read: product placement) just for you. Ambient commercials will also hijack your attention by using tastes and smells, with the ultimate goal of beaming buy-me messages directly into your brain.
9 TURING TESTERS Computer engineers will continue to measure their efforts to mimic human intelligence, as British mathematician Alan Turing suggested 50 years ago, by asking you whether you're talking to a person or a machine. By the time you can't tell the difference, these human simulators will be used as unflappable customer service reps as well as Internet attaches who can summarize your e-mails and even write back: "Hi, Mom, sorry I missed your call..."
10 KNOWLEDGE ENGINEERS Artificial-intelligence brokers will translate your expertise into software, then downsize you.
...and what jobs will disappear?
1 STOCKBROKERS, AUTO DEALERS, MAIL CARRIERS, INSURANCE AND REAL ESTATE AGENTS The Internet will eradicate middlemen by the millions, with a hardy few remaining to service the clueless. You'll cut us a deal, right, HAL?