Got Any Good Drugs?
Gene-spliced medicines will replace what surgeons do and fit
like a tailored suit
by FREDERIC GOLDEN
It was a blast of a New Year's party, but now that 2024 is
history and 2025 is here, you're feeling terrible. It's not just
a hangover. You're sweating. You're listless. You're aching all
over. The doctor nods sympathetically while she pokes around
here and there as physicians have done ever since Hippocrates.
Then she goes high tech: "Your gene card, please?" she asks.
The computer digests the rectangle of plastic you hand her. "Yes,
you've got a bad case of flu," she says reassuringly. "I'm having
the pharmacy create a drug for you. It'll be ready before you're
dressed, and you should be as good as new by tomorrow."
Maybe that's not exactly the way pills will be dispensed 25 years
from now, but you can be sure that at molecular biology's current
pace, it will be something like that. By then scientists will
have decoded the entire human genome--all 140,000 or so genes that
largely say who we are and which of 4,000 diseases our flesh is
heir to. They will also have found exactly where common
disease-causing errors lie along the genome's long, interlocked
chains of DNA.
That will have enormous practical consequences. Your genetic
profile, recorded on a chip, will let doctors--or, more likely,
their computerized diagnostic tools--determine your exact level of
risk for a particular disease and which proteins and enzymes your
body lacks. There will be no more wasteful trial and error, with
costly pills winding up in the trash because they produced
unwelcome reactions or didn't work for you. Instead you'll get
customized prescriptions, created to "fit" on the very first try,
like a Savile Row suit.
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