Best Inventions of 2001

Inventions come in all shapes and sizes. Some are as simple as purple catsup. Others push the limits of quantum physics. The real measure of an invention is not just how well it works or how impressively it is engineered, but how it changes our lives.

Artificial Liver

2001 inventions of the year health liver

William Mercer McLeod for TIME

Inventor: Dr.Kenneth Matsumura, Alin Foundation

he liver is one of the most complex organs in the body—and one of the hardest to replace. It removes toxins from the blood and manufactures up to 1,000 proteins, metabolites and other vital substances. Now scientists trying to develop an artificial liver have found a way around these complexities: they let rabbit-liver cells do the work. The Bio-Artificial Liver developed by Dr. Kenneth Matsumura has a two-part chamber—patient's blood on one side, live rabbit cells suspended in a solution on the other—with a semipermeable membrane in between. As toxins from the blood pass through the membrane, the rabbit cells metabolize them and send the resulting proteins and other good things back to the other side. Because the rabbit cells never come into direct contact with human blood, the chances of infection or rejection are minimized. The device, now in its final stage of clinical trials, is meant primarily as a "bridge to an eventual liver transplant for patients with acute liver failure or for those who have rejected a previous transplant. In some cases, it may also give a damaged liver time to heal on its own, eliminating the need for a transplant altogether.

Availability: In 2002
To Learn More: www.alinfoundation.com

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