In fact, Fleming was not even the first to describe the antibacterial properties of Penicillium. John Tyndall had done so in 1875 and, likewise, D.A. Gratia in 1925. However, unlike his predecessors, Fleming recognized the importance of his findings. He would later say, "My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist." Although he went on to perform additional experiments, he never conducted the one that would have been key: injecting penicillin into infected mice. Fleming's initial work was reported in 1929 in the British Journal of Experimental Pathology, but it would remain in relative obscurity for a decade.

By 1932, Fleming had abandoned his work on penicillin. He would have no further role in the subsequent development of this or any other antibiotic, aside from happily providing other researchers with samples of his mold. It is said that he lacked both the chemical expertise to purify penicillin and the conviction that drugs could cure serious infections. However, he did safeguard his unusual strain of Penicillium notatum for posterity. The baton of antibiotic development was passed to others.

In 1939 a specimen of Fleming's mold made its way into the hands of a team of scientists at Oxford University led by Howard Florey, an Australian-born physiologist. This team had technical talent, especially in a chemist named Ernst Boris Chain, who had fled Nazi Germany. Armed with funding from the Rockefeller Foundation, these scientists made it their objective to identify and isolate substances from molds that could kill bacteria. The mission was inspired by the earlier work of Gerhard Domagk, who in 1935 showed that the injection of a simple compound, Prontosil, cured systemic streptococcal infections. This breakthrough demonstrated that invading bacteria could be killed with a drug and led to a fevered search in the late 1930s for similar compounds. Fleming's Penicillium notatum became the convenient starting point for Florey's team at Oxford.

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